A Clinically Realistic Large Animal Model of Intra-Articular Fracture

Abstract

The primary objective of this project is to develop a novel large animal survival model of intra-articular fracture (IAF) in which all major pathophysiological attributes of corresponding human clinical injuries are realistically replicated, and in which post-traumatic osteoarthritis (OA) predictively develops. Work during the reporting period (Year 1) has yielded definitive protocols to create a large animal survival IAF model and to document/analyze the natural course of fractured experimental joints in this model. In PY-3, documentation/analysis of the natural course data will be continued. Simultaneously, using the protocols established in the last two project years, the 7-day survival study to test the effect of a therapeutic treatment will be pursued.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA570059

Entities

People

  • Yuki Tochigi

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anesthesia
  • Animal Diseases
  • Arthritis
  • Bone Fractures
  • Cartilage
  • Cell Physiological Processes
  • Confocal Microscopy
  • Data Analysis
  • Diseases And Disorders
  • Health Services
  • Measurement
  • Orthopedic Surgical Procedures
  • Orthopedics
  • Regression Analysis
  • Surgery
  • Survival
  • Three Dimensional

Readers

  • Computational Modeling and Simulation
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology