Identification of Genes and Genetic Variants Associated with Poor Treatment Response in Patients with Prostate Cancer
Abstract
The first year of this grant has already resulted in an informative set of DNA, high risk pedigrees, and phenotype data for a set of pedigrees representing an excess of a highly significant clinic subset of prostate cancer cases: those who will go on to die of the disease. Our initial linkage analysis of less than 200 cases has already significantly confirmed a previously reported linkage on chromosome 1. In addition, our initial linkage analysis of less than 200 cases has already identified a significant linkage on chromosome 11. This initial linkage manuscript is in preparation. We will now collaborate (with other funding) to begin sequence analysis of the regions of interest. Identification of genes predisposing to recurrent/lethal prostate cancer from this study will validate this powerful approach, which can be extended to other high risk prostate cancer pedigrees, and will identify genes and pathways that can be further examined to expand our knowledge of prostate cancer genetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA570345
Entities
People
- Craig Teerlink
- Lisa Cannon-Albright
- Neeraj Agarwal
Organizations
- University of Utah