The Influence of Metabolic Syndrome on Prostate Cancer Progression and Risk of Recurrence in African American and European American Men
Abstract
The objective of this study was to establish whether metabolic syndrome plays a role in the progression of prostate cancer and the influence of metabolic syndrome and/or its individual features on the progression of prostate cancer between African American men (AAM) and European American men (EAM). From our results we conclude that both hypertension and metabolic syndrome (defined by possessing 3 of the 4 measured features) are associated with high Gleason grade disease at the time of diagnosis among EAM (but not among AAM). We also conclude that hypertension and diabetes are associated with increased risk for biochemical recurrence and again the relationship appears stronger for EAM than it is for AAM. Further we suggest from these findings that metabolic syndrome and its features among AAM may be associated with early prostate cancer (early in the natural history ofthe disease). This would be consistent with case-control reports of metabolic syndrome. A recent Swedish report of European men with metabolic syndrome found no evidence of an association between high levels of metabolic factors and the risk of prostate cancer, but high BMI, elevated blood pressure and a composite score of all metabolic factors were associated with an increase risk of death fi om prostate cancer. These reports are similar to our findings. The totality of the evidence seems to suggest that the biology of prostate cancer is different between AAM and EAM, where features of metabolic syndrome are associated with prostate cancer risk (initiation) in AAM they seem to be associated with progression of disease in EAM.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA570389
Entities
People
- Isaac Powell
- Jennifer L Beebe-Dimmer
- Lance Heilbrun
Organizations
- Wayne State University