Role of the Inflammasome in Asbestos-Induced Mesothelioma Formation

Abstract

The investigations proposed in this idea award grant are aimed at addressing the requirement of asbestos-induced inflammation in the pathogenesis of malignant mesothelioma (MM). Cancer-related inflammation (CRI) within the tumor microenvironment contributes to tumor progression in many human malignancies. MM tumor samples have hallmarks of CRI including macrophage infiltration and inflammatory cytokine production. We intend to evaluate the role of asbestos-induced inflammation in the formation of MM by genetically and pharmacologically inhibiting inflammasome-mediated inflammation in mouse models of MM and determine whether this physiological response is required for tumor development. The overarching goal is to provide the first in vivoevidence of whether inflammation directly contributes to the development of asbestos-induced MM. The proposed investigations may also implicate inflammasome-mediated CRI as a potential target for the prevention or treatment of MM.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA570536

Entities

People

  • Joseph R. Testa

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Asbestos
  • Biomedical Research
  • Body Fluids
  • Body Weight
  • Cancer
  • Cells
  • Culture Techniques
  • Cytokines
  • Department Of Defense
  • Diseases And Disorders
  • Fibers
  • Inflammasomes
  • Inflammation
  • Macrophages
  • Mesothelioma
  • Neoplasms
  • Pathogenesis

Fields of Study

  • Medicine

Readers

  • Educational Psychology
  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech