Genome Instability: A Common Link in Gulf War Illness Patients

Abstract

The objective of this proposal is to determine whether there is a link between genome instability (reflected as elevated frequencies of NCCAs) and GWI. Patient samples (blood) are being directly analyzed using molecular cytogenetic analyses and gene expression studies. The central hypothesis of this proposal is that patients with GWI will display high levels of genome instability, particularly when challenged by various toxic agents, which can be stochastically linked to various molecular pathways and is the potential basis for diverse clinical symptoms that are seen in GWI.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA570587

Entities

People

  • Henry Heng
  • Saroj Chowdhury

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cell Physiological Processes
  • Cells
  • Chromosome Aberrations
  • Chromosomes
  • Chronic Fatigue Syndrome
  • Frequency
  • Gene Expression
  • Genomic Instability
  • Instability
  • Persian Gulf Syndrome
  • Statistical Analysis

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.