A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microdevice has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with TBI using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, open-loop stimulation does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA570590

Entities

People

  • Randolph J Nudo

Organizations

  • University of Kansas Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cerebral Cortex
  • Cognitive Impairment
  • Diseases And Disorders
  • Microelectrodes
  • Neural Pathways
  • Neurons
  • Neuroplasticity
  • Neurosciences
  • Prostheses And Implants
  • Prosthetics
  • Recovery
  • Spinal Cord
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.