A Comparison of Proximal Tibia and Proximal Humerus Infusion Rates of Plasma Under High Pressure Using the EZ IO Intraosseous Device in the Adult Swine (Sus scrofa) Hypovolemic Model
Abstract
Purpose: Evaluate use of plasma admin via IO under pressure >300mmHg in proximal humerus and tibia, establish which IO sites reach higher flow rate, and eval for pulmonary fat emboli-FE post IO infusion. Method:2 groups of swine-16 each intubated and ventilated. Central venous and arterial lines placed; blood removed at rate of 2.15ml/min for 7min, then 1.15ml/min for 13min. Swine observed with no treatment for 1hr. EZIO needle inserted; plasma reinfused for 10min. Lung samples eval for signs of FE. Findings: The mean weight, vol removed and infusion pressure were similar in both groups. Mean vol plasma infused 490mL tibia and 649mL humerus. Mean infusion rate was 49mL/min(SD22mL/min) tibia and 78mL/min(SD43mL/min) humerus p<0.02. Survival rate 94% tibia, 88% humerus p<0.33. Humerus serum lactate elevated during 1hr post bleed; decreased post plasma infusion; tibia elevated until EOS. Histo revealed FE present 88% tibia, 94% humerus. Conclusion:IO infusion rate of plasma in humerus greater than tibia in swine model. Majority of swine had FE in lungs. Further studies needed to eval safety of high pressure infusion in IO device.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 10, 2013
- Accession Number
- ADA570999
Entities
People
- Julio Lairet
- Vikhyat S Bebarta
Organizations
- 59th Medical Wing