Glycomic Analysis of Prostate Cancer

Abstract

We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions; analysis of the IgA/IgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2012
Accession Number
ADA571105

Entities

People

  • Radoslav Goldman

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Blood Proteins
  • Chemistry
  • Cirrhosis
  • Diseases And Disorders
  • Genomics
  • Health Services
  • Hepatitis
  • Liver Diseases
  • Mass Spectrometry
  • Neoplasms
  • Polysaccharides
  • Prostate Cancer
  • Proteomics
  • Spectrometry
  • Substance-Related Disorders

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