Therapeutic Correction of Thrombin Generation in Dilution-Induced Coagulopathy: Computational Analysis Based on a Data Set of Healthy Subjects

Abstract

Prothrombin complex concentrates (PCCs), which contain different coagulation proteins, are attractive alternatives to the standard methods to treat dilution-induced (and, generally, traumatic) coagulopathy. We investigated the ability of a novel PCC composition to restore normal thrombin generation in diluted blood. The performance of the proposed PCC composition (coagulation factors [F] II, IX, and X and the anticoagulant antithrombin), designated PCC-AT, was compared with that of FVIIa and PCC-FVII, which is the PCC composition containing FII, FVII, FIX, and FX (main components of most PCCs).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA571182

Entities

People

  • Alexander Y. Mitrophanov
  • Frits R. Rosendall
  • Jaques Reifman

Organizations

  • United States Army Medical Research and Development Command

Tags

DTIC Thesaurus Topics

  • Anticoagulants
  • Application Software
  • Biomedical Research
  • Blood
  • Blood Coagulation
  • Blood Coagulation Factors
  • Combat Casualty Care
  • Data Sets
  • Demographic Cohorts
  • Department Of Defense
  • Dilution
  • High Performance Computing
  • Network Science
  • Proteins
  • Prothrombin
  • Standards
  • Therapy

Readers

  • Computational Linguistics
  • Trauma Surgery or Emergency Medicine.