Hsf1 in Her2-Positive Breast Cancer

Abstract

This study demonstrates that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, via control of the oncogene-induced senescence, and progression, via regulation of tumor angiogenesis. It also dissects the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrates that Hsf1 regulates expression of the major angiogenesis factor HIF- 1, and this regulation involves the translation regulator HuR. This program provides rationale for development of Hsf1 inhibitors that can inhibit multiple pathways in tumor initiation and progression. It also establishes a simple xenograft model that can be used for anti-Hsf1 drug testing.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA571331

Entities

People

  • Michael Sherman

Organizations

  • Boston University

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Breast Cancer
  • Cardiovascular Diseases
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Enzyme Inhibitors
  • Infection
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Rna Stability
  • Transcription Factors

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).
  • Systems Analysis and Design