Role of Natural Killer T Cells In Immunogenic Chemotherapy for Breast Cancer
Abstract
During this first year of investigation, we have highlighted the important role of gamma delta T cells in the efficacy of immunogenic chemotherapy using anthracyclines. In the meantime, the NKT cells seem to be dispensable for this effect at least in this particular situation. Moreover, we have also identified a population of gamma delta T cells with a unique phenotype never described before (CD3[expn bright]). Interestingly, this population has a clear intrinsic ability to produce IL-17 compared to any other gamma delta T cells and are represented at a high frequency in breast cancer tumor environment. Our future efforts will focus on this population and their putative role in immunogenic chemotherapy for breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA571626
Entities
People
- Christophe Paget
- Helene Duret
- Mark J. Smyth
Organizations
- University of Melbourne