Red Blood Cell Immune Complex Binding Capacity in Children with Sickle Cell Trait (HbAS) Living in P. falciparum Malaria Holoendemic Region of Western Kenya

Abstract

Malaria infection leads to the formation of circulating immune complexes (CICs) which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait (HbAS) are less predisposed to getting severe manifestations of malaria. We carried out a study to determine the competence of the red blood cells (RBCs) of children with HbAS to bind immune complexes (ICs) and compared this with normal hemoglobin (HbAA).

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Document Details

Document Type
Technical Report
Publication Date
Dec 08, 2012
Accession Number
ADA571728

Entities

People

  • Benson Ba. Estambale
  • Joash R. Aluoch
  • Jose A. Stoute
  • Michael M. Odera
  • Walter Otieno

Organizations

  • United States Army Medical Research Unit-Kenya

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Age Groups
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Data Analysis
  • Diseases And Disorders
  • Erythrocytes
  • Hematologic Diseases
  • Hemoglobin
  • Infection
  • Infectious Diseases
  • Malaria
  • Oxygenation
  • Proteins
  • Sickle Cells
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Exercise and Sports Science.
  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.