Evaluate the Mechanism of Enhanced Metastasis Induced by Arthritis

Abstract

Breast cancer remains the second leading cause of cancer related deaths for women in the United States. Metastasis is regulated not only by intrinsic genetic changes in malignant cells, but also by the microenvironment, especially those associated with chronic inflammation. We have reported that mice that suffer from autoimmune arthritis have significantly increased incidence of bone and lung metastasis and decreased survival associated with breast cancer. In this study, we evaluated the mechanism underlying the increased metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA572977

Entities

People

  • Lopamudra Das Roy

Organizations

  • University of North Carolina at Charlotte

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Biomedical Research
  • Blood
  • Bone Marrow
  • Bone Marrow Cells
  • Breast Cancer
  • Cell Movement
  • Cells
  • Epithelial Cells
  • Growth Factors
  • Lymphocytes
  • Mammary Glands
  • Mast Cells
  • Neoplasms
  • Tissues
  • United States
  • X Rays

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech