Novel and Efficient Synthesis of the Promising Drug Candidate Discodermolide
Abstract
During the second year of this grant, we have exploited our new stereotriad building blocks and prepared a major structural component of the target. Thus we prepared two key intermediates and linked them to obtain the C-1 to C-13 stretch of discodermolide. One-carbon homologation with the Stork Zhao reaction gave the C-1 to C-14 stretch, appropriate for connection with our stereopentad piece. We also modified the building block synthesis in order to prepare anti, anti stereotriads and we initiated a new and improved scheme to the polypropionate building blocks that bear a Z-vinyl iodide.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2008
- Accession Number
- ADA573041
Entities
People
- Kathlyn A. Parker
Organizations
- State University of New York