Targeting Energy Metabolic Pathways as Therapeutic Intervention for Breast Cancer
Abstract
During this grant period, we obtained evidence that eukaryotic elongation factor-2 kinase (eEF-2K) plays a key role in the regulation of cellular energy metabolism in breast cancer cells. We demonstrated that silencing of eEF-2K led to a greater reduction of cellular ATP and lactate. We further showed that suppression of eEF-2K impeded tumor cell growth in the serum/nutrient-deprived cultures, handicapped cell survival, and enhanced the efficacy of growth factor antagonist gefitinib and lapatinib, ER stressors thapsigargin and tunicamycin, in breast cancer cells. The results of the first grant year study have identified eEF-2K as a novel regulator of cancer cell metabolism, and provide new evidence that targeting eEF-2K may represent a novel approach to enhancing the effectiveness of anti-cancer reagents such as growth factor inhibitors and ER stress inducers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA573205
Entities
People
- Yan Cheng
Organizations
- Pennsylvania State University