Dynamic Tissue Culture System from Prostate Biopsy Specimens as a Model for Predicting Tumor Radio-sensitivity to Ionizing Radiation Treatments. Addendum

Abstract

The underlying hypothesis driving this project is the notion that all prostate carcinomas are not the same (even if they have the same clinical stage, Gleason score, and pretreatment PSA). By studying individual tumor specimens from patient s prostate carcinomas prior to treatment, it will be possible to obtain information that will make it possible to understand the pathologic factors and molecular regulators that are involved in determining radiation induced apoptosis and intrinsic radio-sensitivity. Our long term goal, for which this proposal will be the first stop, is to develop a system to better individualize each patient s treatment based on various clinical, pathological and molecular biological parameters, thereby maximizing the treatment potential benefit to the patient, while also minimizing the potential treatment toxicity to the patient

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA573268

Entities

People

  • Jonathan Walker

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biological Sciences
  • Biomedical Research
  • Biopsy
  • Cell Physiological Processes
  • Department Of Defense
  • Electronic Mail
  • Ionizing Radiation
  • Molecular Biology
  • Prostate
  • Radiation
  • Regulators
  • Sensitivity
  • Tissue Culture
  • Tissues
  • Toxicity
  • Universities

Fields of Study

  • Medicine
  • Physics

Readers

  • Operations Research
  • Prostate Cancer Biology.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.