Treatment of Traumatic Brain Injury by Localized Application of Subatmospheric Pressure to the Site of Cortical Impact

Abstract

Each major war tends to have a signature injury , with traumatic brain injury (TBI) associated with the Iraq war (Operation Iraqi Freedom II and Operation Enduring Freedom) due to the high incidence of personnel injured by IED (improvised explosive devices). The large gyrencephalic brain of swine is similar to humans, thus a swine model of a controlled cortical impact (CCI injury) treated by the controlled application of sub-atmospheric pressure was employed. Work completed in Year 2 showed that application of 100 mm Hg to the site of the CCI for 5 days was necessary to prevent a late increase in intracranial pressure (ICP). Four of the 10 animals treated with 100 mm Hg vacuum for 3 days showed an increase in intracranial pressure. Thus, application of 100 mm Hg sub-atmospheric pressure for five days was necessary to prevent a late increase in intracranial pressure.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA573367

Entities

People

  • Michael Morykwas

Organizations

  • Wake Forest University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Afghanistan Conflict
  • Bandages
  • Barometric Pressure
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Explosive Devices
  • Explosives
  • Improvised Explosive Devices
  • International Organizations
  • Iraqi-War
  • Medical Personnel
  • War

Readers

  • Combustion science or combustion engineering.
  • Neurotrauma and Rehabilitation Medicine.