A Search for Gene Fusions/Translocations in Breast Cancer
Abstract
Previously, we completed the molecular/ biochemical characterization of several shortlisted candidate gene fusions from the transcriptome sequencing of over 70 previously validated samples. From these studies, we identified two rare but recurrent gene fusions in breast cancer cell lines and tissues involving the MAST and Notch genes. Both of these fusion genes are potentially targetable and patients harboring MAST or Notch fusions may benefit from MAST or Notch inhibitors. Functional characterizations of the fusion genes in various in vivo and in vitro assays are ongoing. In this reporting period of our ongoing project, Search for Gene Fusions/Translocations in Breast Cancer , we extended upon the analysis of gene fusions in breast cancer to examine amplicon-associated gene fusions and their functional significant. We also describe a novel study of cancer-specific pseudogenes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA573505
Entities
People
- Arul Chinnaiyan
Organizations
- University of Michigan