Glycomic Analysis of Prostate Cancer

Abstract

In this proposal, we are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. The study population is assembled and an annotated sample repository is ready for use. Methods for the glycomic analysis of fractionated proteins are in place. We have evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis finds some connections to glycosylation. We have now analyzed pooled and unpooled samples of men by optimized analyses of fractionated serum in order to evaluate the glycomic changes in prostate cancer health disparity. The analysis and the interpretation of results is ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA573586

Entities

People

  • Radoslav Goldman

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • African Americans
  • Biomedical Research
  • Blood Proteins
  • Caucasians
  • Data Analysis
  • Diseases And Disorders
  • Disparities
  • Gene Expression
  • Genomics
  • Health
  • Immunoglobulins
  • Instructions
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins

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