Expression of Proteins Involved in Epithelial-Mesenchymal Transition as Predictors of Metastasis and Survival in Breast Cancer Patients

Abstract

The purpose of this research is to investigate protein expression and promoter region DNA methylation status of six genes involved in epithelial-mesenchymal transition in relation to breast cancer lymph node metastasis, recurrence, and survival. Breast tumor tissue has been retrospectively identified from the Pathology Resource and immunohistochemical staining for all proteins has been completed. DNA from these tumor tissues has been obtained. Analyses of IHC-stained tissues and DNA methylation are ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2012
Accession Number
ADA573715

Entities

People

  • Austin Miller
  • Christine Ambrosone
  • Gokul Das
  • Jo L Freudenheim
  • Michael Higgins
  • Michelle Roberts
  • Wiam Bshara

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Data Analysis
  • Diseases And Disorders
  • Epidemiology
  • Genetics
  • Health Services
  • Lymph Nodes
  • Lymphatic System
  • Metastasis
  • Methylation
  • Neoplasms
  • Survival
  • Transitions

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.