Effect of Teriparatide, Vibration, and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Abstract

Severe bone loss commonly occurs in individuals with chronic spinal cord injury who are non-weightbearing and leads to an increased risk of lower extremity fractures. This 12 month , multi-site, double-blind, randomized, placebo-controlled study evaluates the efficacy and safety of two interventions known to be anabolic to bone, parathyroid hormone and mechanical loading (Provided as teriparatide and vibration, respectively) in 60 SCI individuals with low bone mass. At the end of the second year of this project, 80 participants have been screened and 28 enrolled with 6 currently in the run-in phase. Disposition of the 28 subjects enrolled includes 3 participants who have completed the study. 24 Active and 1 who has Discontinued. No safety issues have arisen during the study. Results regarding efficacy will only be available at the completion of the trial.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA573751

Entities

People

  • Thomas J Schnitzer

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Bone Diseases
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Information Operations
  • Lower Extremity
  • Musculoskeletal Diseases
  • Musculoskeletal Physiology
  • Osteoporosis
  • Parathyroid Hormones
  • Spinal Cord
  • Spinal Injuries
  • Vibration

Readers

  • Clinical Trial Research.
  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.