Investigations of Tissue-Level Mechanisms of Primary Blast Injury Through Modeling, Simulation, Neuroimaging and Neuropathological Studies

Abstract

Traumatic brain injury (TBI) to U.S. soldiers has become one of the most taxing consequences of IED attacks in OEF/OIF. This project has focused on investigations of traumatic injury to the brain caused by the primary effects of blast waves. The project combines clinical, experimental and modeling studies aimed at: (i) elucidating the cell and tissue-level mechanisms of injury produced by the effect of the blast wave, (ii) deriving associated blast injury criteria (metrics and thresholds), (iii) helping to identify and treat returnees suffering from TBI, and (iv) developing blast protection strategies for TBI mitigation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 10, 2012
Accession Number
ADA573887

Entities

People

  • Cameron Bass
  • David Moore
  • Ghatu Subhash
  • James Deshler
  • K. Taber
  • R. Hurley
  • Raúl Radovitzky
  • S. Socrate
  • Steve Son
  • Wayne Chen

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain Injuries
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Dynamic Response
  • Explosions
  • Explosive Devices
  • Explosives
  • Geometry
  • Improvised Explosive Devices
  • Measurement
  • Mechanical Properties
  • Medical Personnel
  • Military Research
  • Petn
  • Pressure Measurement
  • Students

Readers

  • Explosive Engineering.
  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.