Biomarkers for Pulmonary Injury Following Deployment
Abstract
To understand the risks of lung disease faced by soldiers, USACEHR has studied a rat model of lung disease after instillation of dust or silica. After exposure, lung pathology was measured and we identified the proteins and microRNAs that were released into the lung lavage fluid at different times after exposure so that the markers could be correlated with the observed pathology. In this model silica affected the lung more than dust from Iraq, and we reported the proteins and microRNAs we found in lavage fluid after either treatment. The candidate biomarkers we found came from lavage fluid which is relatively accessible. The markers we found can now be compared to markers from human clinical specimens. This work is underway via a collaboration with the STAMPEDE project at BAMC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2013
- Accession Number
- ADA574075
Entities
People
- Joseph S Brown
- Kai Wang
- Richard Gelinas
Organizations
- Institute for Systems Biology