Defining a Role for the Oncogene Beta-Catenin in Prostate Epithelial Growth and Invasion

Abstract

We are investigating the molecular basis of prostate development in order to understand the pathways which control prostate epithelial differentiation, proliferation, and invasion. In the last year, we were able to develop and validate a new system for interrogation of gene function in prostate development. Using this model, we demonstrated an absolute requirement for canonical Wnt signaling in prostate lineage specification and bud formation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA574100

Entities

People

  • Brian W. Simons

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkenes
  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Developmental Biology
  • Inhibition
  • Medical Personnel
  • Prostate
  • Public Health
  • Schools
  • Small Molecules
  • Specifications
  • Students
  • Tissues
  • Universities
  • Virotherapy

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Prostate Cancer Biology.
  • Systems Analysis and Design