Shock Wave-Stimulated Periosteum for Cartilage Repair

Abstract

The primary objective of this project is to determine if extracorporeal shock wave (ESW)-stimulated periosteum improves cartilage repair when it is used as an autograft to fill a defect in the articular surface of goats. A miniature fiber optic pressure sensor will be inserted into the tibial periosteum of 6 animals to measure the actual shock waveform in the tissue for two ESW doses (energy densities). In 12 goats, tibial periosteum stimulated by one of the 2 doses of ESWs (n=6) will be harvested, 4 days post-treatment, as an autograft for implantation into one 1 cm2 defect surgically produced in the trochlear groove of the knee joint of the same goat. Non-ESW-treated periosteum will serve as the control group (n=6). All animals will be sacrificed after 16 weeks, and the reparative tissue will be quantified histomorphometrically by determining the areal percentage of selected tissues in the original cartilage defect area.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2012
Accession Number
ADA574132

Entities

People

  • Hu-ping Hsu
  • Myron Spector

Organizations

  • Boston VA Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Autografts
  • Biomedical Research
  • Bone And Bones
  • Bone Diseases
  • Cartilage
  • Connective Tissue
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Hematomas
  • Information Operations
  • Joints (Anatomy)
  • Shock
  • Shock Waves
  • Tissues
  • Waves

Readers

  • Trauma Surgery or Emergency Medicine.