Imaging Molecular Signatures of Breast Cancer with X-ray-Activated Nanophosphors
Abstract
The first year of this research program developed the foundation for Radioluminescence Imaging (RLI) and Radioluminescence Tomography (RLT). The second year of this research program, detailed in this report, was dedicated to optimizing the instrumentation for the RLT imager, developing a technique to image multiple phosphor targets simultaneously, and creating the instrumentation for percutaneous imaging of RLI. Overall, sensitivity has been improved to a level on par with fluorescent imaging. The inclusion of a filter wheel to spectrally select the phosphor photon emission has enabled multiplexed imaging, which was shown to linearly quantify multiple molecular contrasts simultaneously, saving time and resources; this system was demonstrated in small animal phantoms. The percutaneous RLI system was developed to enable imaging of targeted nanophosphors through a biopsy needle. This system is able to fit in a standard 10 gauge biopsy needle. We have thus completed aims 1, 2, and 3 of the grant. We are beginning aim 4: pre-clinical testing in a small animal breast tumor model. This preclinical testing will be performed in our RLT imager. For this second round of funding, we have an additional 1 peer-reviewed journal publications, and 4 more conference abstracts for this project as a direct result of this funding. The cumulative total results of this grant is: 7 journal publications, including 3 first author; 12 conference abstracts, and 4 courses taken. Several postdoctoral fellows are now being mentored and working in RLI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA574280
Entities
People
- Colin M. Carpenter
Organizations
- Stanford University