Improvements in Diagnostic Accuracy with Quantitative Dynamic Contrast Enhanced MRI

Abstract

We have continued scanning patients with the calibration phantoms and a research scanning protocol that allows us to acquire quantitative images of the breast displaying concentration of contrast media. These data can be used to generate maps displaying different parameters descriptive of contrast uptake, and pharmacokinetics, which are diagnostically useful. A subset of patients has been scanned at two field strengths (1.5T and 3T). Analysis of these data indicates a reduction in the variation across the scans with the quantitative methods proposed. By analyzing the sources of variability in the quantitative results, we aim to reduce differences across different fields even more. To date, 32 patients have been scanned with the calibration phantoms, 11 of them at two field strengths. Recruitment is ongoing, as well as refinement of our methods in order to increase their reliability.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2012
Accession Number
ADA574372

Entities

People

  • Federico Pineda

Organizations

  • University of Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Acquisition
  • Biomedical Research
  • Breast Cancer
  • Calibration
  • Cancer
  • Contrast
  • Contrast Media
  • Data Acquisition
  • Heavy Water
  • Images
  • Magnetic Resonance
  • Mathematical Models
  • Measurement
  • Models
  • Reliability
  • Scanning

Fields of Study

  • Medicine
  • Physics

Readers

  • Image Processing and Computer Vision.
  • Oncology (Cancer Research).
  • Regression Analysis.