Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR-CAT)

Abstract

Cardiopulmonary resuscitation (CPR) can save victims of normovolemic cardiac arrest (CA), e.g., ventricular fibrillation. During exsanguination CA from trauma, however, CPR, even with an emergency department (ED) thoracotomy and open chest CPR, doesn t work. Emergency Preservation and Resuscitation (EPR) was developed to rapidly preserve the organism during ischemia, using hypothermia, drugs, and fluids, to buy time for transport and resuscitative surgery. The purpose of this study is to test the feasibility of rapidly inducing profound hypothermia (< 10oC) with an aortic flush in trauma victims that have suffered CA and failed standard resuscitative efforts to enable resuscitative surgery and delayed resuscitation with cardiopulmonary bypass. The primary outcome variable will be survival to hospital discharge with minimal neurologic dysfunction.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA574471

Entities

People

  • Patrick M. Kochanek
  • Samuel A. Tisherman

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Animal Training
  • Biomedical Research
  • Cardiac Arrest
  • Cardiac Arrhythmias
  • Cardiopulmonary Resuscitation
  • Department Of Defense
  • Electronic Mail
  • Emergencies
  • Health Services
  • Hemorrhagic Shock
  • Hypothermia
  • Information Operations
  • Institutional Review Board
  • Medical Personnel
  • Resuscitation
  • Students
  • Universities

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma or Military Medicine