Identification of Small Molecule Inhibitors of microRNA Involved in Chemoresistance and Cancer Stem Cells for Ovarian Cancer Intervention

Abstract

During last year, we have screened NCI Diversity Set, Nature Compound and Clinical Collection 1 and 2 libraries using cell-based assay and have identified 22 and 35 candidate compounds that inhibit miR-19a/b and miR-221/222, respectively. Furthermore, we have characterized the specificity of these candidates as well as potential inhibitors of miR-214 and have identified 2 specific inhibitors for miR-214, 3 for miR-221/222 and 2 for miR-19a/b. We are currently investigating their antitumor activity in cell culture and animal model.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2012
Accession Number
ADA574634

Entities

People

  • Jin Q. Cheng

Organizations

  • H. Lee Moffitt Cancer Center & Research Institute

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Gene Expression
  • Inhibitors
  • Lymphocytes
  • Molecules
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Small Molecules
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Optical Physics and Photonics.

Technology Areas

  • Biotechnology