A Biomathematical Model of the Restoring Effects of Caffeine on Cognitive Performance During Sleep Deprivation
Abstract
Rationale: While caffeine is widely used as a countermeasure to sleep loss, mathematical models are lacking. Objective: Develop a biomathematical model for the performance-restoring effects of caffeine in sleep-deprived subjects. Methods: We hypothesized that caffeine has a multiplicative effect on performance during sleep loss. Accordingly, we first used a phenomenological two-process model of sleep regulation to estimate performance in the absence of caffeine, and then multiplied a caffeine-effect factor, which relates the pharmacokineticpharmacodynamic effects through the Hill equation, to estimate the peperformance-restoringffects of caffeine. Results: We validated the model on psychomotor vigilance test data from two studies involving 12 subjects each: (1) single caffeine dose of 600 mg after 64.5 h of wakefulness and (2) repeated doses of 200 mg after 20, 22, and 24 h of wakefulness. Individualized caffeine models produced overall errors that were 19% and 42% lower than their population-average counterparts for the two studies. Had we not accounted for the effects of caffeine, the individualized model errors would have been 117% and 201% larger, respectively. Conclusions: The presented model captured the performance-enhancing effects of caffeine for most subjects in the single- and repeated-dose studies, suggesting that the proposed multiplicative factor is a feasible solution.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2013
- Accession Number
- ADA575496
Entities
People
- Gary H. Kamimori
- Jaques Reifman
- Nancy J. Wesensten
- S. Laxminarayan
- Sridhar Ramakrishnan
- Srinivasan Rajaraman
- Thomas J Balkin
Organizations
- United States Army Medical Research and Development Command