Nanofiber Nerve Guide for Peripheral Nerve Repair and Regeneration

Abstract

The primary goal of this collaborative research project is to develop next generation engineered nerve guide conduits (NGCs) with aligned nanofibers and favorable release kinetics of neurotrophic factors to help improve surgical outcomes after injuries involving peripheral nerves. In the second year of the work, we further improved the gradient loading of the neurotrophic factor GDNF (Glial cell derived neurotrophic factor) and tested various combinations of NGCs in a rat sciatic nerve regeneration model. We have also started the IACUC application for the large animal validation study using the peroneal nerve repair in dogs.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2013
Accession Number
ADA575734

Entities

People

  • Ahmet Höke
  • Hai-Quan Mao

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Collagen
  • Culture Techniques
  • Demographic Cohorts
  • Fibers
  • Growth Factors
  • Materials
  • Nanofibers
  • Nerves
  • Neuroglia
  • Peripheral Nervous System
  • Sciatic Nerve
  • Tissues
  • Validation

Readers

  • Nanocomposite Materials Science
  • Neuroscience
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology