Identification and Targeting of Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis
Abstract
Current treatments for advanced prostate cancer are not very effective. To develop better treatment options, new approaches to investigate the signaling pathways important for advanced prostate cancer are warranted. Tyrosine kinase signaling contributes to numerous pathologies including cancer. In prostate cancer, mutation rates of tyrosine kinases are not readily observed, however, tyrosine phosphorylation of advanced prostate cancer is quite abundant indicating activity of tyrosine kinases are apparent even in the absence of activating mutations. Work supported by this award investigated this and found robust tyrosine phosphorylation in advanced prostate cancer in both human and mouse tumors. Using commonly perturbed non-tyrosine kinase oncogenes and pathways found in prostate cancer, phosphopeptide enrichment and quantitative mass spectrometry analysis revealed oncogene-specific tyrosine kinase signatures. Analysis of these signatures revealed unique tyrosine kinase signaling networks which may be targeted in advanced prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA575949
Entities
People
- Justin M Drake
- Owen N Witte
Organizations
- University of California, Los Angeles