Early Whole Blood for Patients Requiring Massive Transfusion after Major Trauma

Abstract

Severe uncontrollable coagulopathy in major trauma patients continues to be a major factor in trauma mortalities. This proposal will implement a randomized, controlled trial of early whole blood transfusions in high risk, major trauma patients to determine if whole blood can prevent or control severe coagulopathy compared to standard massive transfusion care (currently 1:1 ratio of FFP to PRBC). Second, this proposal will determine if we can accurately predict major trauma patients who will require massive transfusion within 20 minute of arrival to the emergency department. Finally, this study aims to test commonly utilized point of care analysis and determine its reliability in early prediction of transfusion needs. Two connected sub-projects under the leadership of Dr. Charles Wade and Dr. Rosemary Kozar are associated with this project and are further discussed in the text of the report.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2013
Accession Number
ADA577325

Entities

People

  • Bryan A. Cotton
  • Charles E Wade
  • Rosemary A. Kozar

Organizations

  • University of Texas at Austin

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Factors
  • Biomedical Research
  • Blood
  • Blood Groups
  • Blood Transfusions
  • Brain Injuries
  • Clinical Trials
  • Data Analysis
  • Data Mining
  • Health Services
  • Hemorrhagic Shock
  • Information Science
  • Patient Care
  • Point-Of-Care Diagnostic Testing
  • Statistical Analysis
  • Therapy

Fields of Study

  • Medicine

Readers

  • Research Science/Academic Research
  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine