SIRT3 Is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis

Abstract

The mammalian Sirtuin genes are homologs of the yeast Saccharomyces cerevisiae Sir2 gene that is implicated in the regulation of longevity (Haigis et al., 2012). There are seven Sirtuin proteins, with SIRT1, SIRT6, and SIRT7 localized in the nucleus, SIRT2 localized in the cytoplasm and SIRT3, SIRT4, and SIRT5 localized in the mitochondria (Finkel et al., 2009). The mitochondrial deacetylase SIRT3 is thought to act on numerous substrates to regulate several processes including fat and amino-acid metabolism as well as electron transport (Huang et al., 2010).

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA577369

Entities

People

  • Sarki Abdulkadir

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Antibodies
  • Biological Staining And Labeling
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Mammary Glands
  • Metabolism
  • Neoplasms
  • Substrates
  • Suppressors
  • Tissues
  • Validation

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and Cellular Biology
  • Trauma or Military Medicine

Technology Areas

  • Biotechnology
  • Microelectronics