Physiological Feedback Control 2011-2012 Annual Report

Abstract

The research completed within this contract focused on the development of a platform that reverses the effects of an analgesic overdose (Tasks 1-3), and the development a platform that reverses the effects associated with organophosphate poisoning (Task 4). We successfully scaled up the synthesis of the naloxone prodrug that was designed and tested during Phases I and II, and documented its efficacy in a pig model. Although we had proposed to develop a long-acting form of ketamine, regulatory issues prevented us from moving that project forward. Finally, we designed a novel class of dendrimer-oxime drug conjugates, and evaluated the mechanism by which these conjugates hydrolyze paraoxon.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 07, 2013
Accession Number
ADA577420

Entities

People

  • Abraham Van Der Spek
  • Baohua Huang
  • Brent Ward
  • Clara Verweij
  • James R. Baker Jr.
  • Pascale Leroueil
  • Seok K. Choi
  • Thommey Thomas

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Analgesia
  • Blood
  • Cardiovascular Physiological Phenomena
  • Chemical Synthesis
  • Chemistry
  • Liquid Chromatography
  • Mass Spectrometry
  • Medical Personnel
  • Organic Chemistry
  • Oxygenation
  • Pain
  • Pain Management
  • Physiological Monitoring
  • Poisoning
  • Rodents
  • Statistical Analysis
  • Veins

Readers

  • Clinical Trial Research.
  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.