Intravenous Fat Emulsion Therapy Versus Sodium Bicarbonate Effect on Hypotension and QRS Measurement in a Swine Model (Sus scrofa) of Diphenhydramine Toxicity
Abstract
Obj:Compare IV fat emulsion(IFE) and sodium bicarbonate(SB) in critically ill diphenhydramine(DPH) swine to determine which better improves hypotension(hypo). Method:Swine 45-55kg infused with DPH 1mg/kg/min IV until MAP fell to 60% of baseline (BL), randomized to IFE or SB. Measured HR, SBP, MAP, CO, SVR, & SvO2. Labs for pH, pCO2, bicarb, lactate, & DPH level. DPH level found by liquid chromatography. Results:24 swine, 12 each to IFE & SB group. At BL, vital signs similar in each group. IFE & SB group had similar amt of DPH to hypo(IFE: 31.21mg/kg; SB: 33.28mg/kg). IFE to hypo at mean 32:13min; SB at 34:08min. Post hypo, no difference in IFE & SB groups for CO, SVR, SvO2, QRS, or QTc; though, better HR in SB, SBP in IFE, & MAP in IFE. IFE group died at mean 12:33min; SB at 07:48min. One IFE and two SB pigs survived. Mean total serum DPH levels end of study similar. Mean DPH in lipid layer was 6.8mcg/mL, in aqueous layer 8.6mcg/mL. Conc:No difference in hypo between IFE & SB. IFE didn't improve QRS widening in DPH toxic swine. DPH level similar in aqueous & lipid layers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 13, 2012
- Accession Number
- ADA578611
Entities
People
- Brett Pearce
- Maria Castaneda
- Shawn Varney
- Susan Boudreau
- Toni Vargas
- Vikhyat
Organizations
- 59th Medical Wing