Critical Review of Selected Components of RIPD (Radiation-Induced Performance Decrement)

Abstract

RIPD (Radiation-Induced Performance Decrement) is a physiologically-based model of acute radiation sickness (ARS). RIPD estimates: severity of illness due to prompt or protracted exposures to ionizing radiation for total free-in-air doses between 0.75 Gy and 45 Gy; residual performance capability over time for soldiers exposed to ionizing radiation in a military engagement; incidence of performance decrement; incidence of lethality; time to lethality. The RIPD model applies to whole-body exposures to gamma rays and/or neutrons; dose-rate histories can be complex and the exposure period can be as long as one week. RIPD estimates severity of illness and performance capability for up to 1000 hours (about 6 weeks) after the start of exposure. The prompt exposure models in RIPD were developed during the Defense Nuclear Agency's Intermediate Dose Program (IDP) to facilitate consequence assessment and military planning in a nuclear radiation environment. This report (1) summarizes RIPD's performance decrement model, and (2) reviews the four kinetic models around which RIPD's sign/symptom (S/S) severity model structure is built and through which RIPD extends the IDP's prompt exposure S/S severity models to protracted radiation exposures. The assumptions, limitations, and mathematical structure of these four physiologically-based models are discussed.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2012
Accession Number
ADA578704

Entities

People

  • Darren R. Oldson
  • Terry C. Pellmar

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Army Personnel
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Gamma Rays
  • Health
  • Immune System
  • Ionizing Radiation
  • Lymphocytes
  • Medical Personnel
  • Military Planning
  • Nuclear Radiation
  • Radiation Effects
  • Radiation Sickness
  • Regression Analysis
  • Stem Cells

Fields of Study

  • Physics

Readers

  • Computational Modeling and Simulation
  • Nuclear and Radiation Engineering.