Towards DNA-Based Programmable Matter

Abstract

We completed a series of pilot studies towards the development of DNA-programmed mesoscale and nanoscale materials. We developed a computational and experimental infrastructure that enabled the translation of arbitrary three-dimensional models into DNA sequences that encode their assembly. We developed a suite of surface chemistries to functionalize a variety of mesoscale materials with DNA oligonucleotides. Finally, we demonstrated the ability of these DNA-linked surfaces to mediate surface-surface interactions in a DNA sequence-specific manner. In a second line of research, we applied these principles to create higher-older nanometer-scale plasmonic structures from DNA-linked gold nanospheres and nanoshells.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 2012
Accession Number
ADA579302

Entities

People

  • David Gorin
  • David R. Liu
  • Jia Niu
  • John Sadowski
  • Yu He

Organizations

  • Harvard University

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Algorithms
  • Chemical Synthesis
  • Chemistry
  • Computer Programs
  • Electric Fields
  • Electromagnetic Fields
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Metallic Nanoparticles
  • Military Research
  • Nanoparticles
  • Nanostructures
  • Nanotechnology
  • Self Assembly
  • Surface Chemistry
  • Two Dimensional

Readers

  • Molecular Genetics
  • Nanocomposite Materials Science
  • Nanoscale Plasmonic Nanotechnology