Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells

Abstract

Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2012
Accession Number
ADA579479

Entities

People

  • Andre Nussenzweig

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • B Lymphocytes
  • Biomedical And Dental Materials
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Genetics
  • Genomic Instability
  • Hematologic Diseases
  • Instability
  • Ionizing Radiation
  • Neoplasms
  • Proteins
  • Stem Cells

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and genetic basis of cancer.