Metabolomic Profiling of Prostate Cancer Progression During Active Surveillance

Abstract

This report covers the first year of funding of this project. The goal of the project is to identify a metabolomics signature, measured on biopsy tissue, serum, or urine, that can distinguish men with only Gleason score 6 tumor in their prostate vs. men whose biopsy indicates Gleason score 6 but who harbor higher grade (Gleason score > 7) tumor that was not sampled by the biopsy. This report deals largely with unanticipated problems resulting in patient and tissue accrual that are behind schedule, and our plans to rectify these problems and get the study on track during Year 2.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA579522

Entities

People

  • Bruce J Trock

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Disease Attributes
  • Diseases And Disorders
  • Laboratory Animals
  • Laboratory Procedures
  • Materials
  • Medical Personnel
  • Metabolomics
  • Neoplasms
  • Pathology
  • Phenotypes
  • Pilot Studies
  • Prostate
  • Prostate Cancer
  • Recombinant Dna
  • Surveillance
  • Tissues

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Systems Analysis and Design