Role of Complement in Red Cell Dysfunction in Trauma
Abstract
Our preliminary data on RBC deformability, Ca++ influx and NO production suggest that the increased complement deposition on RBCs in patients with trauma may lead to the cytoskeletal changes in RBCs. This mechanism may retard the ability of RBCs to travel through capillaries and subsequently affect the delivery of O2 to the tissues. Thus understanding the pathophysiological relevance of complement activation and red cell dysfunction after trauma will provide a rationale to design pharmacological strategies that can prevent complement-RBC mediated post-traumatic mortality.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2012
- Accession Number
- ADA579523
Entities
People
- George Tsokos
Organizations
- Beth Israel Deaconess Medical Center