Acute Lethality of Inhaled Hydrogen Cyanide in the Laboratory Rat: Impact of Concentration x Time Profile and Evaluation of the Predictivity of Toxic Load Models
Abstract
Toxic load models are mathematical calculations (e.g., C[expn n] x t) that are used to estimate consequences (e.g., casualties)from exposure of humans to toxic materials. Hypothetically, any combination of concentration and time that yields the same "toxic load" (cumulative exposure) will give a constant biological response. These formulas have been developed using controlled, constant concentration animal studies, but the validity of applying these assumptions to time-varying exposures has not been tested. The objective of the current study was to generate data to test the validity of toxic load models for extrapolation from constant exposures to time-varying exposures. An inhalation system was developed to create exposure profiles where concentration varied over time. This system proved to be a versatile inhalation exposure system with the ability to control the testing conditions of time-varying exposures as specified in the study protocol to accomplish the specific goals of the study; the system performed very well. Analyses evaluating the fit to the probit model indicated that the data developed using this system are suitable for the dose-response modeling that will be integral to the hypothesis testing.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 03, 2013
- Accession Number
- ADA579551
Entities
People
- Brian A. Wong
- Brian Sharits
- Lisa M. Sweeney
- Nathan M. Gargas
- R. A. James
- Tracy Doyle
Organizations
- Naval Medical Research Unit Dayton