Terminating Platinum-Initiated Cation-Olefin Reactions with Simple Alkenes
Abstract
The en masse cyclization of polyolefins into polycyclic terpenoids by cyclase enzymes (e.g. squalene to hopene), is a biosynthetic reaction of particular fascination to chemists. Noteworthy recent additions to synthetic mimics of the cyclase enzymes are asymmetric methods that include Br nsted Lewis acids (BLA), masked equivalents of Br+ and I+, organocatalysts, and electrophilic metal catalysts. With the exception of HgII reagents, few electrophilic metal catalysts cyclize polyenes with bio-like alkene terminators. The development of methods whose catalysts can initiate, cyclize, and terminate polyenes under ligand control would significantly advance the state of the art.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 05, 2011
- Accession Number
- ADA579557
Entities
People
- Chandra S. Korapala
- Jennifer J. Becker
- Joseph G. Sokol
- Michel R Gagné
- Peter S. White
Organizations
- United States Army Research Laboratory