Blast Concussion mTBI, Hypopituitarism, and Psychological Health in OIF/OEF Veterans

Abstract

Studies of traumatic brain injury from all causes have found evidence of chronic posttraumatic hypopituitarism (PTHP) in 25-50% of cases. PTHP, and in particular adult growth hormone deficiency (GHD), is associated with symptoms resembling those of PTSD, include fatigue, anxiety, depression, irritability, insomnia, sexual dysfunction, cognitive deficiencies, and decreased quality of life. However, the prevalence of PTHP after blast related milt TBI (mTB) has not previously been characterized. We have measured concentrations of 12 pituitary and target-organ hormones in two groups of male US Veterans of combat in Iraq or Afghanistan: one group with blast-related mTBI and a second group with similar deployment histories but without blast eposure.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2013
Accession Number
ADA579686

Entities

People

  • Charles Wilkinson

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Combat Injuries
  • Endocrine Glands
  • Health Services
  • Human Behavior
  • Injury Prevention
  • Medical Personnel
  • Military Medicine
  • Psychiatry

Fields of Study

  • Medicine
  • Psychology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Neurotrauma and Rehabilitation Medicine.