Mitochondrial Damage: A Diagnostic and Metabolic Approach in Traumatic Brain Injury and Post-Traumatic Disorder

Abstract

Our specific aims are: a) determine if blood based dipstick test of mitochondrial damage can predict the severity of metabolic failure and brain injury after TBI or TBI with preexisting stress (PTSD+TBI), b) study pyruvate as a countermeasure to mitigate mitochondrial functions in injured brain. Male Sprague Dawley rats with TBI, PTSD and PTSD+TBI were treated with/out pyruvate. We found that even one week after TBI, the metabolic, neurobehavioral parameters and expression of cellular proteins were altered. Blood base dipstick test of PDH enzyme as a biomarker of mitochondrial damage showed a good correlation. Pyruvate treatment showed neuroprotective properties in spite of muscle damage.

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Document Details

Document Type
Technical Report
Publication Date
Jan 29, 2013
Accession Number
ADA579698

Entities

People

  • Brandi Benford
  • Erin Berry
  • He Li
  • Neil Grunberg
  • Pushpa Sharma

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Dna Microarrays
  • Health Services
  • Medical Personnel
  • Neurodegeneration
  • Proteins
  • Traumatic Stress Disorder

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.