Canonical Wnt Signaling as a Specific Marker of Normal and Tumorigenic Mammary Stem Cells

Abstract

We have determined that the Wnt/B-catenin signaling pathway is active within a small subset of cells within the gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical WNT signaling may be very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2013
Accession Number
ADA579924

Entities

People

  • Bart O. Williams

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Confocal Microscopy
  • Epithelium
  • Genes
  • Genetically Modified Organisms
  • Genetics
  • Hormones
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Stem Cells
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology