On the Origin of Prostate Cancer Stem Cells through Transmissible ER Stress-Mediated Epithelial to Mesenchymal Transition

Abstract

This DoD Innovation grant was based on the hypothesis that transmissible ER stress (TERS) promotes Epithelial to Mesenchymal Transition (EMT) in differentiated prostate cancer cells, programming cancer towards a different phenotype and greater invasive characteristics. The hypothesis predicted a new and potentially important mechanism in tumorigenesis. Through the work performed during the last year, we have been able to demonstrate a link between prostate tumor ER stress and EMT. The study is not finished yet but we can confidently say that the premises of the original hypothesis have been experimentally validated.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2013
Accession Number
ADA580103

Entities

People

  • Jeffrey J Rodvold
  • Kevin Chiu
  • Maurizio Zanetti

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Endoplasmic Reticulum
  • Genes
  • Genetics
  • Neoplasms
  • Phenotypes
  • Programmed Cell Death
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Transitions

Readers

  • Molecular Biology and Genetics
  • Systems Analysis and Design

Technology Areas

  • Biotechnology