The Function of Neuroendocrine Cells in Prostate Cancer
Abstract
The goal of the project is to determine the function of neuroendocrine (NE) cells in the initiation and progression of human prostate cancer Scope: 1) Use a pten null mouse prostate cancer model to determine if ablation of NE cells by selective expression of a toxin in these cells can delay or prevent tumor initiation and/or progression. 2) Use a human tissue recombination model to determine if depletion of NE cells from human epithelial cells can retard the initiation and progression of the recombinant tumor. 3). Demonstrating the origin and molecular basis of human small cell carcinoma Major findings: 1). We have demonstrated that NE cells are not required for tumor initiation in a pten knockout mouse prostate cancer model. 2). Preliminary studies indicate that NE cells may play an important role in the progression of prostate cancer to the castration resistant stage in the pten knockout model. 3). With the tissue recombination model, tumors can be generated using the NE cell-depleted basal cells, suggesting that NE cells are not required for tumor initiation. 4). In the tissue recombination model, NE cells are not required for the propagation of established tumors. 5). NE cells are incapable of initiating small cell neuroendocrine carcinoma in the tissue recombination model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2013
- Accession Number
- ADA580194
Entities
People
- Jiaoti Huang
Organizations
- University of California, Los Angeles