Randomized Controlled Trial of Sertraline, Prolonged Exposure Therapy and Their Combination of OEF/OIF with PTSD

Abstract

The current proposal aims to directly compare the psychotherapy and medication treatments for PTSD considered to have the most evidence for effectiveness. While both SSRI and PE have demonstrated efficacy, there are significant individual differences in clinical responses to both treatments. To achieve best clinical outcomes and to utilize available treatment most effectively, it is critical to examine how PTSD and related psychopathology and functional impairment change with these treatments alone and in combination. Further, in order to inform clinical practice, we plan to examine psychological and neurobiological predictors of response to treatment and mechanisms of change during treatment (pre to post treatment change) based on previously identified predictors, including emotion regulation and processing with fMRI in response to emotional challenge tasks, DNA (pre treatment only) and mRNA (pre and post treatment), and cortisol response to awakening.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2011
Accession Number
ADA580287

Entities

People

  • Sheila Rauch

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Active Duty
  • Afghanistan Conflict
  • Biomedical Research
  • Clinical Trials
  • Contracts
  • Delivery Of Health Care
  • Department Of Defense
  • Diseases And Disorders
  • Health Services
  • Instructions
  • Iraqi-War
  • Laboratory Procedures
  • Public Health
  • Therapy
  • Training
  • Universities

Fields of Study

  • Medicine
  • Psychology

Readers

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