X-Ray Phase Imaging for Breast Cancer Detection
Abstract
Aiming to develop a low-dose and quantitative x-ray phase imaging technique for facilitating breast cancer detection, in this project we designed and built a high-voltage x-ray imaging prototype that enables x-ray phase imaging and radiation dose reduction, as is demonstrated in phantom imaging. We developed an innovative phase attenuation duality based (PAD-based) method, which greatly facilitating the low doe phase retrieval for soft tissue body parts such as breast. The phantom imaging demonstrated that the PAD-based phase retrieval greatly enhance the contrast-to noise ratios of images, hence it has good potential for reducing radiation doses in breast imaging. We also developed a robust general phase retrieval method, the attenuation-partition based (AP-based) method for general clinical imaging. This method was demonstrated to be superior to the mostly used phase retrieval method in literature in performing robust phase retrieval for low-dose imaging. Considering the high breast density is one of the biggest risk factors for breast cancer, we proposed for the first time an x-ray phase-shifts based method of breast density measurement, as a quantitative imaging method of the phase-sensitive breast imaging.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA580565
Entities
People
- Xizeng Wu
Organizations
- University of Alabama